The Missing Link between HAART, Mitochondrial Damage and Insulin Resistance

GAPDH: the missing link between glycolysis and mitochondrial oxidative phosphorylation?

The main function of glycolysis and oxidative phosphorylation is to produce cellular energy in the form of ATP. In the present paper we propose a link between both of these energy-regulatory processes in the form of GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and CytOx (cytochrome c oxidase). GAPDH is the sixth enzyme of glycolysis, whereas CytOx is the fourth complex of the mitochondrial ...

Is visceral fat the missing link in the relationship between inflammation and insulin resistance in RA?

A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance.

The transition from young to adult age is associated with decreased insulin sensitivity. To investigate whether changes in skeletal muscle mitochondrial function could be involved in the development of insulin resistance, we measured the oxidative capacity and energetic efficiency of subsarcolemmal and intermyofibrillar mitochondria isolated from the skeletal muscle of 60- and 180-day-old rats....

The missing link between hydrogenosomes and mitochondria.

Mitochondria typically respire oxygen and possess a small DNA genome. But among various groups of oxygen-shunning eukaryotes, typical mitochondria are often lacking, organelles called hydrogenosomes being found instead. Like mitochondria, hydrogenosomes are surrounded by a double-membrane, produce ATP and sometimes even have cristae. In contrast to mitochondria, hydrogenosomes produce molecular...

The Missing Link - between Requirements and Design

The combination of complex system design and management today requires a profound understanding of the relationships between the requirements and design processes throughout the product life cycle. To practice Systems Engineering merely as a technical matter is a serious misjudgment. Engineering is an interdisciplinary approach for all those involved in the Product Creation Process (PCP). The s...